Human Proteome Map deciphering 84% of human proteins published

Jun 2, 2014 12:30 IST

Human Proteome Map (HPM) deciphering 84% of human proteins was published in British Journal Nature on 28 May 2014. This is for the first time that a near complete protein maps of human beings.

The draft map of human proteome was drawn by an international team of scientists led by Akhilesh Pandey of the Johns Hopkins University in the U.S and Harsha Gowda at the Institute of Bioinformatics in Bangalore.

The proteins deciphered have been derived from 30 histologically normal human samples and have been encoded from 17294 genes. The identified proteins cover more than 84% of the annotated protein-coding genes in humans. The number of identified proteins, as per the study, stands at 30057.

The draft map of the human proteome was prepared using high-resolution Fourier-transform mass spectrometry.

The research could offer deeper insight into why humans suffer from diabetes, cancer and cardiac problems among other diseases.

From bacteria to humans, genes are made up of units of DNA known as base pairs. The sequence of base pairs in genes informed about a cell's molecular machinery what proteins to produce. Ultimately, it is the proteins that carry out a myriad processes essential for life.

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