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IIT Madras C-STROKE Atlas: In the course of the visit of the Hon’ble Prime Minister, Narendra Modi at IIT Madras, the Sudha Gopalakrishnan Brain Centre (SGBC) unveiled C-STROKE – the first ever ischemic stroke atlas of human brain. This unique database has been developed as a publicly available, global platform, thanks to its funding through philanthropy from the distinguished alumnus of IITM, Mr. V. Prem Watsa.
This groundbreaking database has been created by combining clinical pre-mortem MRIs and whole-brain high resolution, microscopic, 3D cellular imaging. C-STROKE consists of 1,000 + annotated brain tissue slices, which include critical cellular level markers related to stroke pathology – including neuron damage, neuroinflammation, disrupted blood-brain-barrier, hypoxia, and axonal damage. The platform is supported by the Param Shakti supercomputer and will help neuroscientists, researchers and clinicians around the world study cerebrovascular disorders and develop cellular therapeutics for humans.
IIT Madras C-STROKE Human Ischaemic Stroke Atlas: Key Highlights
Below are the key ighlights related to the IIT Madras C-STROKE Human Ischaemic Stroke Atlas:
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Feature Parameter |
Platform Details |
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Developing Facility |
Sudha Gopalakrishnan Brain Centre (SGBC), IIT Madras |
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Official Launch Authority |
Prime Minister Narendra Modi |
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Platform Name & Type |
C-STROKE (Open-Access Human Ischemic Stroke Atlas) |
|
Primary Beneficiary Partner |
Philanthropic support from Distinguished Alumnus Mr. V. Prem Watsa |
|
Data Volume & Features |
Over 1,000 annotated brain sections mapping cellular-level biomarkers |
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Imaging Integration |
Bridges pre-mortem clinical MRI with high-resolution cellular histology |
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Access Model |
Free, open-access digital portal for global clinicians and researchers |
IIT Madras Key Cellular Biomarkers Mapped in C-STROKE
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Neuronal Status: Displays microscopic detail of fine structures and breakdowns in ischemic areas.
Neuroinflammation: Follows inflammation markers and gliosis following stroke occurrence.
Blood-Brain Barrier (BBB) Breakdown: Charts structural breakdowns on cerebrovascular walls.
Hypoxia & Axonal Injury: Detects areas of hypoxia and axonal injury of nerve bundles.
