A team of scientists in the second week of January 2012 identified a group of cancer cells that play a main role in preventing the development of the disease. This scientific finding could lead to re-evaluation of common cancer treatment for patients.
It pointed out that anti-angiogenic therapies that target those tumour cells- called pericytes- inadvertently make tumours more aggressive. The study was published in the journal Cancer Cell. It underscores the need of more research on tumour-cell composition to bring out more effective therapies.
For the study, the team of scientists created genetically modified mice to support drug-induced depletion of pericytes in growing tumours. They then deleted pericytes in their cancer tumours, decreasing pericyte numbers by 60 percent.
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