IAS Main Medical Science Question Paper I - 2010

The Union Public Service Commission (UPSC) holds the Civil Services Examination every year in two parts, i.e. Preliminary Test and Main Examination; the Main Examination comprises a written Test and a Personality Test. The Question paper of the IAS Main Medical Science Paper I  –2010 is given as below:

MEDICAL SCIENCE

Paper-I

Time Allowed: Three Hourse

INSTRUCTIONS

Maximum Marks: 300

Each question is printed both in Hindi and in English.

Answer must be written in the medium specified in the Admission Certificate issued to you, which must be stated clearly on the cover of the answer-book in the space provided for the purpose. No marks will be given for the answers written in a medium other than specified  in the Admission Certificate.

Candidates should attempt Question Nos. 1 and 5 which are compulsory. and any three of the remaining questions selecting at least one question from each Section.

The Number of marks carried by each question is indicated at the end of the question.

Wherever required, the candidates may use coloured pencils for drawing sketches and diagrams in the answer book.

SECTION A

1. Answer any five of the following:

(a) Explain the origin and course of Facial Never. Describe its functional components and distribution. What is Bell's palsy and give the anatomical reasons for the presenting signs?           4+6+2= 12

(b) Describe the blood supply and lymphatic drainage of stomach. Add a note on the applied anatomy of both.   9+3= 12

(c) Define sleep. Write briefly on architecture of a sleep cycle .What are the variations in it with age ?   3+5+4=12

(d) Write the steps in lactation. What are the advantages of breast feeding ?   3+9=12

(e) How are deletions in 'gene causing diseases' detected ? Explain in terms of Duchenne Muscular Dystrophy (DMD).   12

(f) Chronic rental failure leads to Osteodystrophy. Outline the chain of events.   12

2. (a) Describe the ventricles of brain. Add a note on the circulation of CSF. Mention the usual site of collection of CSF. Mention the usual site of collection of CSF and state the anatomical reason for selecting this site.                    14+4+2=20

(b) Describe the development of heart chambers. Mention the common congential anomalies and explain the developmental reasons for them. 14+6=20

(c) Describe the gross anatominal features and relations of kidney. Explain its arterial supply and vascular segments. Add a note on the development of kidney.    10+5+5=20

3. (a) What is the role of ADH in maintaining the plasma osmolarity and volume? What will happen in its deficiency ?   

                                                                                                                                        8+8+4= 20

(b) Write the morphology of red blood corpuscles. List the factors required for their formation and mention how the shape is advantageous. 5+10+5= 20

(c) Enumerate the functions of cardiovascular system. What will happen if values would not have been there ?   15+5=20

4. (a) Substantiate the following statements:    20

(a) Substantiate the following statement:   20

" Deficiency of a trace element leads to diminished glocose tolerance."

(b) The use of oral contraceptives appears to increase the requirement of a vitamin which vitamin is involved ? Explain why. How is this identified clinically ?    20

(c) Explain :

(i) Non- standard amino acids and their biological functions.

(ii) Importance of enzyme assay to assess liver function.    10+10=20

SECTION B

5. Attempt any five of the following:

(a) Discuss the role of FNAC and biopsy in the diagnosis of neoplasms of Breast. Briefly mention the different histopathological types of breast carcinoma.     6+6=12

(b) What are the predisposing factors in the etiology of oral cancer ? Briefly describe the malignant lesions that are likely to affect the oral cavity.  6+6=12

(c) Name the SHIGELLA  species causing diseases in man. Desrcribe the pathogenesis of Bacillary dysentery. What are the laboratory procedures in the diagnosis of Bacillary dysentery? Mention how laboratory finding in Bacillary dysentery are different from those of Amoebic dysentery.  12

(d) Discuss the mechanism of action of the following drugs:    12

(i) Rosiglitazone

(ii) Chloroquine

(iii) Cyclosporin

(iv) Lovostation

(e) Write about the clinical status (use) of the following drugs:  12

(i) Tamoxifen

(ii) cis-platinum

(iii) Griseofulvin

(iv) Chloramphenicol

(f) Enumerical the various types of injuries. Describe the injuries produced by a sharp weapon.      12

6. (a) Define Cirrhosis of Liver. Classify the different cirrhotic conditions of the liver. Discuss the etiopathogenesis and pathology of primary biliary cirrhosis.                                                                                      3+6+3+3=15

(b) What are the possible contributing factors in the genesis of Bronchogenic Carcinioam ? Briefly describe thye bpathologic fature of the different carcinomas of the bronchus. What are the problems in early diagnosis of this disease ?  4+8+3=15

(c) What are Immunoglobulins ? Classify Immunoglobulins. Describe their role in host defence against communicable diseases. What are antigens ?     15

(d) What is the etiology of Epidemic Meningitis ? Describe the laboratory methods in the diagnosis of Epidemic meningitis. Compare the laboratory findings with those of Aseptic meningitis.   15

7. Write about the difference between the following druges:    15×4=60

(a) Aspirin and Paracetamol

(b) Nitrolycerin and Verapamil

(c) Prazosin and Atenolol

(d) Captopril and Losartan

8. (a) Describe the mechanism of injuries sustained by a pedestrian on being hit by a four- wheeler.  20

(b) how will you plan to collect and preserve the samples for DNA profiting and other tests in a cases of mass disaster having mutilated and dismembered bodies ?    20

(c) Describe the signs, symptoms and treatment of acute parathion poisoning.   20