The US team of scientists found the mechanism in the hypothalamus- which is located deep inside the brain- and showed that it is responsible for the ageing process. Scientists carried out a series of experiments to find that they could extend the lives of mice by a fifth, without the problems such as animals suffering from muscle weakness, bone loss or memory problems associated with old age.
Scientists discovered that a chemical called NF-kB became more active in the hypothalamus of mice as they reached old age. When they blocked NF-kB, mice lived up to 1100 days, compared with 600 to 1000 days in normal condition. But all the mice died within 900 days, when NF-kB was given to them in abundance.
Further experiment showed that NF-kB reduced levels of a hormone called GnRH, which plays a key role in fertility and the development of sperm and eggs. When the mice were given daily dose of GnRH, it resulted into fresh neurons growing in their brains.
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